A group of animal lovers are victims of an ironic twist of fate when mutant wildlife reign terror over them in this fantastical suspense film. These kind souls, who have convened in the woods of Northern California for a two-week camping trip, are delighted to spend time in the nature that they adore. However, the indigenous animals who greet them are no longer cute, gentle creatures! They have been turned into evil, mutated versions of themselves due to the depletion of the ozone layer.

Los Angeles is being stalked by a seven-foot alien that decapitates its victims and shoots laser beams from its eyes. William Devane is the father of the first victim, and teams up with TV reporter, a rival detective, and a psychic to track "The Mangler" down before it claims its next victim.

This anthology is set within a mental ward at a hospital where doctors try to cope with people suffering from a variety of ailments. Among the afflicted is a young man who believes his parents are really from outer space, a murderous television producer, and a prominent fashion photographer obsessed with a motivational record.